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Drug Topic:- Sacituzumab Govitecan Injection

What is this medication?

SACITUZUMAB GOVITECAN (SAK i TOOZ ue mab GOE vi TEE kan) is a monoclonal antibody combined with chemotherapy. It is used to treat breast cancer and urothelial cancer.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): TRODELVY

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • diarrhea
  • infection (especially a virus infection such as chickenpox, cold sores, or herpes)
  • liver disease
  • low blood counts, like low white cell, platelet, or red cell counts
  • an unusual or allergic reaction to sacituzumab govitecan, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medication?

This medicine is for infusion into a vein. It is given by a healthcare professional in a hospital or clinic setting.

Talk to your pediatrician about the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

Keep appointments for follow-up doses. It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.

What may interact with this medication?

  • certain antivirals for HIV or hepatitis
  • gemfibrozil

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Your condition will be monitored carefully while you are receiving this medicine.

You may need blood work done while you are taking this medicine.

This medicine can cause serious allergic reactions. To reduce your risk, you may need to take medicine before treatment with this medicine. Take your medicine as directed.

Do not become pregnant while taking this medicine or for 6 months after stopping it. Women should inform their health care professional if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine and for 3 months after stopping it. There is potential for serious side effects to an unborn child. Talk to your health care professional for more information.

Do not breast-feed a child while taking this medicine or for 1 month after stopping it.

This medicine may increase your risk of getting an infection. Call your health care professional for advice if you get a fever, chills, or sore throat, or other symptoms of a cold or flu. Do not treat yourself. Try to avoid being around people who are sick.

Avoid taking medicines that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your health care professional. These medicines may hide a fever.

This medicine has caused ovarian failure in some women. This medicine may make it more difficult to get pregnant. Talk to your health care professional if you are concerned about your fertility.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives; swelling of the face, lips, or tongue
  • diarrhea
  • nausea/vomiting
  • signs and symptoms of infection like fever; chills; cough; sore throat; pain or trouble passing urine
  • signs and symptoms of low red blood cells or anemia such as unusually weak or tired; feeling faint or lightheaded; falls; breathing problems

Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):

  • constipation
  • hair loss
  • headache
  • loss of appetite
  • signs and symptoms of high blood sugar such as being more thirsty or hungry or having to urinate more than normal. You may also feel very tired or have blurry vision.
  • trouble sleeping

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This medicine is given in a hospital or clinic and will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.