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Drug Topic:- Mavacamten

What is this medication?

MAVACAMTEN (mav a KAM ten) treats symptoms caused by a thickened heart muscle (obstructive hypertrophic cardiomyopathy). It works by making it easier for your heart to pump blood to the rest of your body. This improves symptoms and helps you be more active.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): CAMZYOS

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Infection
  • Irregular heartbeat or rhythm
  • An unusual or allergic reaction to mavacamten, other medications, food, dyes or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

Take this medication by mouth with water. Take it as directed on the prescription label at the same time every day. Do not cut, crush or chew this medication. Swallow the capsules whole. You can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your care team tells you to stop.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

Do not take this medication with any of the following:

  • Armodafinil
  • Bexarotene
  • Bosentan
  • Ceritinib
  • Certain antibiotics like isoniazid, nafcillin, rifabutin, rifampin, rifapentine, or telithromycin
  • Certain medications for fungal infections like ketoconazole, isavuconazonium, or posaconazole
  • Cimetidine
  • Dabrafenib
  • Dexamethasone
  • Diltiazem
  • Efavirenz
  • Esomeprazole
  • Felbamate
  • Fluoxetine
  • Idelalisib
  • Lumacaftor; ivacaftor
  • Mifepristone
  • Mitotane
  • Modafinil
  • Nefazodone
  • Nevirapine
  • Paritaprevir
  • Pexidartinib
  • Ribociclib
  • Sotorasib
  • Ticlodipine
  • Tucatinib
  • Ranolazine
  • Verapamil

This medication may also interact with the following:

  • Birth control pills
  • Certain medications for blood pressure, heart disease, irregular heart beat
  • Omeprazole
  • Tolbutamide

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.

Do not become pregnant while taking this medication or for 4 months after stopping it. Women must use a non-hormonal form of birth control while taking this medication. Women should inform their care team if they wish to become pregnant or think they might be pregnant. There is potential for serious harm to an unborn child. Talk to your care team for more information.

Birth control may not work properly while you are taking this medication. Talk to your care team about using an extra method of birth control.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Heart failure—shortness of breath, swelling of the ankles, feet, or hands, sudden weight gain, unusual weakness or fatigue

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Dizziness
  • Feeling faint or lightheaded

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Get rid of any unused medication after the expiration date.

To get rid of medications that are no longer needed or have expired:

  • Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
  • If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, take the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.